ea0015p179 | Endocrine tumours and neoplasia | SFEBES2008
Leontiou Chrysanthia A
, Schmid Herbert
, McSheehy Paul
, Grossman Ashley B
, Korbonits Marta
Background: AMPK is a metabolic enzyme regulating the energy supply of the cell but it has antiproliferative effects as well via the up-regulation of the p53-p21 axis and inhibition of the mTOR-pathway. Somatostatin (SST) analogues reduce hormone secretion from somatotroph adenomas and tumour growth inhibition can also be achieved. SST affect several signalling pathways including the mTOR-pathway. mTOR is a mediator of a pro-proliferative pathway that can be inhibited by activ...